Is It Ordered Correctly? Validating Genome Assemblies by Optical Mapping
نویسندگان
چکیده
منابع مشابه
From sequence mapping to genome assemblies.
The development of "next-generation" high-throughput sequencing technologies has made it possible for many labs to undertake sequencing-based research projects that were unthinkable just a few years ago. Although the scientific applications are diverse, e.g., new genome projects, gene expression analysis, genome-wide functional screens, or epigenetics-the sequence data are usually processed in ...
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Optical mapping is a technology that gathers long-range information on genome sequences similar to ordered restriction digest maps. Because it is not subject to cloning, amplification, hybridisation or sequencing bias, it is ideally suited to the improvement of fragmented genome assemblies that can no longer be improved by classical methods. In addition, its low cost and rapid turnaround make i...
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ژورنال
عنوان ژورنال: The Plant Cell
سال: 2017
ISSN: 1040-4651,1532-298X
DOI: 10.1105/tpc.17.00514